Kelsey Grammer poses with fourth wife Kayte at an earlier event and they were both all smiles.

A report has suggested Kelsey Grammer's pregnant fourth wife Kayte is lonely and miserable while living in Chicago and eight months pregnant with twins.

A source tells RadarOnline:

"Kayte is just absolutely miserable because she feels so lonely and isolated.

"She and Kelsey are living in Chicago right now because he is filming his television series, Boss. Kayte has absolutely no friends and no support network around her."

The chatty source continued:

"Kayte, 32, is alone most of the day while Kelsey is filming and at their recent baby shower for the twins all of the guests were Kelsey's fellow cast members and crew from the show.

Kayte didn't have any of her friends at the shower because they are all in England. It's been a very rough pregnancy for her because she is pregnant with twins. Kayte is hoping that once the babies are born she won't feel so alone."

Kelsey, 57 - who already has four kids, Spencer, 28, and Greer, 19, from previous relationships and 10-year-old Mason and Jude, seven, with ex-wife Camille Donatacci - previously revealed he can't wait for the twins to be born in July.

He said: "I'm really looking forward to meeting these new arrivals in our lives.

"Kayte's one of the most loving, amazing, warm human beings I've ever met."

Kelsey and Kayte suffered heartache when she suffered a miscarriage in October 2010, but the actor revealed last year that he wanted to have more kids because he never "tires" of being with his children.

He explained: "I'd like more kids. I never tire of them. My eldest daughter, Spencer, is expecting my first grandchild.

"Hopefully, my younger children will be able to live with me and Kayte soon. I'm working on it."

(Image: WENN)